1
as in to weaken
to diminish the physical strength of
I don't want our walk to tire you too much
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2
as in to bore
to make weary and restless by being dull or monotonous
this long dry lecture will tire the audience if you don't insert some jokes into it
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3
as in to wear
to use up all the physical energy of
this pentathlon will tire all but the hardiest athletes
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Merriam-Webster unabridged
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