1
as in to infuriate
to cause to change from friendly or loving to unfriendly or uncaring
her changed position on the issue surprised and alienated many of her supporters
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2
as in to cede
to give over the legal possession or ownership of
landowners have a right to alienate their right of ownership—in other words, they can sell the land if they want to
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Merriam-Webster unabridged
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