1
as in hypothesis
an idea that is the starting point for making a case or conducting an investigation
my supposition is that this grape variety, which flourishes in southern France, should do equally well here, given the similar climate
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2
as in guess
an opinion or judgment based on little or no evidence
it's pure supposition on your part that there's something illegal going on next door
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3
as in assumption
something taken as being true or factual and used as a starting point for a course of action or reasoning
worthless genetic research that was based on the erroneous supposition that acquired characteristics can be passed on to offspring
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Merriam-Webster unabridged
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