nucleotide

noun

nu·​cle·​o·​tide ˈnü-klē-ə-ˌtīd 

ˈnyü-

: any of several compounds that consist of a ribose or deoxyribose sugar joined to a purine or pyrimidine base and to a phosphate group and that are the basic structural units of nucleic acids (such as RNA and DNA) compare nucleoside

Examples of nucleotide in a Sentence

Recent Examples on the Web

That includes things like the lipids in our cell membranes, the nucleotides that encode our genes, the amino acids that build most of the working bits of our cells, and other molecules built around bonds between carbon and nitrogen atoms. —Kiona N. Smith, Space.com, 19 Mar. 2025

From its immersion in the language of nucleotides, Evo picks up patterns that humans can’t see. —Ingrid Wickelgren, Quanta Magazine, 5 Feb. 2025

The metaphor leaps out: Like letters of the alphabet, molecules (the nucleotide bases A, T, C and G, for adenine, thymine, cytosine and guanine) are arranged into sequences — words, paragraphs, chapters, perhaps — in every organism, from bacteria to humans. —Ingrid Wickelgren, Quanta Magazine, 5 Feb. 2025

Phosphorus is the structural backbone of the phosphate nucleotides in DNA and RNA, Natalie Hinkel, a planetary astrophysicist at Louisiana State University in Baton Rouge, told me via email. —Bruce Dorminey, Forbes, 20 Jan. 2025

Word History

Etymology

International Scientific Vocabulary, irregular from nucle- + -ide

First Known Use

1908, in the meaning defined above

Phrases Containing nucleotide

• diphosphopyridine nucleotide
• triphosphopyridine nucleotide

Rhymes for nucleotide

• acetamide
• acetonide
• acidified
• antimonide
• beatified
• benzaldehyde
• borohydride
• chalcogenide
• commodified
• decalcified
• declassified
• disaccharide

Kids Definition

nucleotide

noun

nu·​cle·​o·​tide ˈn(y)ü-klē-ə-ˌtīd 

: any of the basic units of structure of DNA or RNA that consist of a base (as adenine, cytosine, guanine, or thymine) joined to a sugar (as deoxyribose) with five carbon atoms in a molecule and to a phosphate group

Medical Definition

nucleotide

noun

nu·​cle·​o·​tide ˈn(y)ü-klē-ə-ˌtīd 

: any of several compounds that consist of a ribose or deoxyribose sugar joined to a purine or pyrimidine base and to a phosphate group and that are the basic structural units of RNA and DNA compare nucleoside