mutation

noun

mu·​ta·​tion myü-ˈtā-shən 

1

: a significant and basic alteration : change

2

: umlaut

3

a

: a relatively permanent change in hereditary material that involves either a change in chromosome structure or number (as in translocation, deletion, duplication, or polyploidy) or a change in the nucleotide sequence of a gene's codons (as in frameshift or missense errors) and that occurs either in germ cells or in somatic cells but with only those in germ cells being capable of perpetuation by sexual reproduction

Mutations known to cause disease have been identified in approximately 1000 genes.

—Alan E. Guttmacher and Francis S. Collins

also : the process of producing a mutation

Microorganisms have been used extensively to study mutation …

—George A. Wistreich et al.

b

: an individual, strain, or trait resulting from mutation

The worst E. coli bacterium, E. coli 0157:H, a mutation discovered in 1982 that has at least sixty-two subtypes, causes hemorrhagic colitis …

—Wayne Biddle

mutational

myü-ˈtā-sh(ə-)nəl 

adjective

mutationally adverb

Examples of mutation in a Sentence

The cat's short tail is the result of mutation.

The condition is caused by a genetic mutation.

The building is a mutation of the original design.

Recent Examples on the Web

But these mutations can evade your immune system. —Michelle Marchante, Miami Herald, 17 Dec. 2025

In the new study, researchers conducted a gene analysis in 182 skin biopsies from tanning bed users and tracked mutation patterns. —Nicole Fallert, USA Today, 16 Dec. 2025

Worryingly, the mutations in the subclade K variant may make this year’s flu vaccine less effective. —Tanya Lewis, Scientific American, 16 Dec. 2025

The study also performed single-cell DNA sequencing on 182 individual melanocytes — the skin cells that produce pigment — and found that cells from tanning-bed users carried about twice as many mutations (or gene changes that can lead to cancer) as those in the control group. —Emily Kay Votruba, EverydayHealth.com, 12 Dec. 2025

Word History

First Known Use

14th century, in the meaning defined at sense 1

Phrases Containing mutation

• back mutation
• gene mutation
• genetic mutation
• point mutation

Rhymes for mutation

• ablation
• bination
• carnation
• cassation
• castration
• causation
• centration
• cessation
• cetacean
• chelation
• citation
• collation

Kids Definition

mutation

noun

mu·​ta·​tion myü-ˈtā-shən 

1

: a basic and important change

2

a

: a permanent change in hereditary material involving either a change in the position of the genes on the chromosomes or a basic change in the chemical structure of a gene

also : the process of producing a mutation

b

: an individual, strain, or trait resulting from mutation

Medical Definition

mutation

noun

mu·​ta·​tion myü-ˈtā-shən 

1

: a relatively permanent change in hereditary material that involves either a change in chromosome structure or number (as in translocation, deletion, duplication, or polyploidy) or a change in the nucleotide sequence of a gene's codons (as in frameshift or missense errors) and occurs either in germ cells or in somatic cells but with only those in germ cells being capable of perpetuation by sexual reproduction

also : the process of producing a mutation

2

: an individual, strain, or trait resulting from mutation

mutational

-shnəl, -shən-ᵊl 

adjective

mutationally

-ē 

adverb