genetic mutation

noun

plural genetic mutations

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.

—Natalie Angier

Examples of genetic mutation in a Sentence

Recent Examples on the Web

Similar to dilated cardiomyopathy, restrictive cardiomyopathy can have a number of potential causes, including genetic mutations, radiation therapy, or chemotherapy. —Elizabeth Millard, TIME, 18 Dec. 2024

All three cases had a distinct genetic mutation that made the bacteria resistant to yet another class of antibiotics, the cephalosporins, which are often used to treat Shigella infections when other drugs fail. —Corinne Purtill, Los Angeles Times, 18 Dec. 2024

And drugs exist that target a very specific genetic mutation in some tumors. —Cory Smith, Baltimore Sun, 20 Nov. 2024

Research suggests that most people with Crohn's disease have a genetic mutation (a permanent change in DNA sequence of a gene) that makes their gut lining cells more vulnerable to damage from a viral norovirus infection, which triggers symptoms.6 6. —Anna Giorgi, Verywell Health, 28 Oct. 2024

Word History

First Known Use

1915, in the meaning defined above

Medical Definition

genetic mutation

noun

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.

—Joseph Alper