monoclonal

1 of 2

adjective

mono·​clo·​nal ˌmä-nə-ˈklō-nᵊl How to pronounce monoclonal (audio)
: produced by, being, composed of, or caused by cells derived from a single cell
… Dr. [Lawrence] Kaplan said tumors that were monoclonal, arising from a single malignant cell, indicated poor survival.Marilyn Chase
especially : relating to, being, or caused by a monoclonal antibody or monoclonal antibodies
monoclonal assays
see also monoclonal gammopathy

monoclonal

2 of 2

noun

plural monoclonals
: monoclonal antibody
But now researchers say that new ways of modifying antibodies promise to deliver monoclonals in more effective forms, with fewer side effects and at lower cost.Lawrence M. Fisher

Examples of monoclonal in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Adjective
As with many monoclonal antibodies, CAB-I47 makes contact with the receptor-binding domain to block binding to the human ACE2 receptor. William A. Haseltine, Forbes, 10 Feb. 2023 Evusheld is a combination of two monoclonal antibodies: tixagevimab and cilgavimab. Carla Delgado, Verywell Health, 8 Feb. 2023
Noun
But in some people living with MS, the disease progresses despite monoclonal treatment. Byjennifer Couzin-Frankel, science.org, 14 Nov. 2024 But for that to work, the monoclonal has to be very highly effective, and to be that effective, the antibodies need to be specific enough to the strain of malaria that’s circulating. Dylan Matthews, Vox, 7 Dec. 2018 See all Example Sentences for monoclonal 

Word History

First Known Use

Adjective

1914, in the meaning defined above

Noun

1980, in the meaning defined above

Time Traveler
The first known use of monoclonal was in 1914

Dictionary Entries Near monoclonal

Cite this Entry

“Monoclonal.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/monoclonal. Accessed 21 Dec. 2024.

Medical Definition

monoclonal

1 of 2 adjective
mono·​clo·​nal ˌmän-ə-ˈklōn-ᵊl How to pronounce monoclonal (audio)
: produced by, being, or composed of cells derived from a single cell
a monoclonal tumor
especially : relating to or being an antibody derived from a single cell in large quantities for use against a specific antigen (as a cancer cell)

monoclonal

2 of 2 noun
: a monoclonal antibody
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