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Mutations in this gene were found to be associated with a syndrome with symptoms that include intellectual disability, seizures, short stature, neurodevelopmental delay, drooling, motor delay, hypotonia (low muscle tone), and microcephaly (having a small head).—Diana Gitig, Ars Technica, 31 May 2024 Symptoms include agitation, hypertonia (too much muscle tone resulting in stiffness), hypotonia (too little muscle tone resulting in floppiness), tremors, drowsiness, and more.—Korin Miller, SELF, 17 Jan. 2019 Just months after being born, Jace Pitre was diagnosed with hypotonia, a condition known as floppy baby syndrome that causes low muscle tone and affects the lungs and heart.—Mike Candelaria, OrlandoSentinel.com, 21 June 2018 This could be due in part to what’s known as muscular hypotonia, or a lower than normal muscle tone.—Amber Brenza, SELF, 31 Mar. 2018
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