heat shock protein

noun

variants or heat-shock protein
plural heat shock proteins or heat-shock proteins
: any of a group of molecular chaperones (see chaperone entry 1 sense 3) that are produced especially in cells subjected to stressful conditions (such as high temperature) and that serve to stabilize proteins and ensure proper assembly and folding of proteins

Word History

First Known Use

1975, in the meaning defined above

Time Traveler
The first known use of heat shock protein was in 1975

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Cite this Entry

“Heat shock protein.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/heat%20shock%20protein. Accessed 10 Sep. 2025.

Medical Definition

heat shock protein

noun
variants or heat-shock protein
: any of a group of molecular chaperones that are produced especially in cells subjected to stressful conditions (such as high temperature or changes in pH) and that serve to stabilize proteins and ensure proper assembly and folding of proteins
Normally, heat-shock proteins protect other proteins inside a cell from being damaged by extreme heat or other stress.Nathan Seppa, Science News
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