downstream

adverb or adjective

down·​stream ˈdau̇n-ˈstrēm 

1

: in the direction of or nearer to the mouth of a stream

floating downstream

located two miles downstream

2

: in or toward the latter stages of a usually industrial process or the stages (such as marketing) after manufacture

improving profits downstream

downstream products

3

biochemistry : toward the end of a series of cellular processes : following a linked molecular event occurring in a sequence

But by looking downstream of the tumor suppressors [genes] at the proteins they influence, drug developers hope to find good targets.

—Marcia Barinaga

Examples of downstream in a Sentence

Recent Examples on the Web

To create the recent Alaskan catalog, Rick spent hours poring over satellite imagery to find glacial lakes that could send water rushing downstream. —Rudy Molinek, Smithsonian Magazine, 9 Sep. 2024

Wade downstream in the Virgin River for 10 to 14 hours, navigating slippery rocks and swift currents. —Outside Online, 14 Aug. 2024

Egypt fears the Grand Ethiopian Renaissance Dam, or GERD, will have a devastating effect on its water and irrigation supply downstream unless Ethiopia takes its needs into account. —Sam Meredith, CNBC, 5 Sep. 2024

The counties also had to get farmers upstream of the dams to use conservation practices on their land that would help hold water and soil on the fields instead of sending it downstream. —Madeline Heim, Journal Sentinel, 15 Aug. 2024

Word History

First Known Use

1591, in the meaning defined at sense 1

Kids Definition

downstream

adverb or adjective

down·​stream ˈdau̇n-ˈstrēm 

: in the direction a stream is flowing

Medical Definition

downstream

adverb or adjective

down·​stream ˌdau̇n-ˈstrēm 

1

: in the same direction along a molecule of DNA or RNA as that in which transcription and translation take place and toward the end having a hydroxyl group attached to the position labeled 3′ in the terminal nucleotide

a nucleotide sequence located downstream from the regulatory gene

effects on the expression of downstream genes

compare upstream sense 1

2

: toward the end of a series of cellular processes : following a linked molecular event occurring in a sequence

But by looking downstream of the tumor suppressors [genes] at the proteins they influence, drug developers hope to find good targets.

—Marcia Barinaga, Science

The tyrosine kinase activity of phosphorylated EGFR [epidermal growth factor receptor] in cancer cells results in the phosphorylation of downstream proteins that incite cell proliferation, invasion, metastasis, and inhibition of apoptosis.

—Jonathan E. Dowell and John D. Minna, The New England Journal of Medicine