Shwartzman reaction

noun

Shwartz·​man reaction ˈshwȯrts-mən-, ˈshwärts- 

: either of two reactions resulting from administration of endotoxin to experimental animals and especially rabbits:

a

: a generalized reaction following two intravenous injections of endotoxin given 24 hours apart and marked by widespread hemorrhage, reduced numbers of white blood cells and platelets, renal necrosis, and death of the animal

called also generalized Shwartzman reaction

b

: a localized cutaneous reaction following subcutaneous injection of endotoxin followed 24 hours later by intravenous injection of endotoxin and marked by hemorrhage, necrosis, and white blood cell infiltration at the site of first injection

called also Shwartzman phenomenon