sclerostin
noun
scle·ros·tin
sklə-ˈräs-tən 
: a glycoprotein produced in osteocytes that inhibits bone formation by suppressing osteoblast differentiation and in a mutated form results in excess bone formation
Romosozumab is a monoclonal antibody directed against sclerostin, a glycoprotein that prevents mesenchymal cells from becoming osteoblasts. By inhibiting sclerostin, romosozumab promotes osteoblast production.—
Bruce Jancin, Frontier Medical News
Bruce Jancin, Frontier Medical NewsSclerostin has been identified as an important regulator of bone homeostasis … and it is involved in the pathogenesis of many different skeletal diseases.—Elias S. Vasiliadis et al., Journal of Clinical Medicine
Elias S. Vasiliadis et al., Journal of Clinical MedicineHumans with genetic deficiencies of sclerostin … have high bone mass, increased bone strength, and resistance to fracture.—Carolyn B. Becker, The New England Journal of Medicine
Carolyn B. Becker, The New England Journal of MedicineDictionary Entries Near sclerostin
Cite this Entry
“Sclerostin.” Merriam-Webster.com Medical Dictionary, Merriam-Webster, https://www.merriam-webster.com/medical/sclerostin. Accessed 30 Dec. 2024.
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