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The following 2 entries include the term orphan!.
orphan disease
noun: a disease which affects a relatively small number of individuals and for which no drug therapy has been developed because the small market would make the research and the drug unprofitable
orphan drug
noun: a drug that is not developed or marketed because its extremely limited use (as in the treatment of a rare disease) makes it unprofitable
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Merriam-Webster unabridged
