endorphin

noun

en·​dor·​phin en-ˈdȯr-fən How to pronounce endorphin (audio)
: any of a group of endogenous peptides (such as enkephalin) found especially in the brain that bind chiefly to opiate receptors and produce some pharmacological effects (such as pain relief) like those of opiates
specifically : beta-endorphin

Did you know?

The word endorphin was coined, back when the substances were discovered in the 1970s, by joining pieces of endogenous and morphine, morphine being a narcotic that closely resembles the endorphins and relieves pain in a similar way. Studies suggest that the pain-relieving practice called acupuncture works by releasing endorphins. Endorphins also seem to play an important role in pregnancy. Though much remains to be learned about the endorphins, the general public seems ready to give them credit for any all-natural high.

Examples of endorphin in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
End result: blood sugar levels off and, at the same time, endorphins are boosted. Lorena Meouchi, Vogue, 19 Mar. 2025 On the flip side, working out—and the release of endorphins—could alleviate pain and menstrual cramps or help with premenstrual dysphoric disorder, or PMDD. Julia Ries, Health, 17 Mar. 2025 The brain needs these hormones to regulate mood and release chemicals in the body called endorphins, which are made in response to stress or pain. Anju Goel, Verywell Health, 13 Mar. 2025 Intellectually, Cousins knew laughter was good for the body, producing endorphins, chemicals produced in the brain that act on the same receptors as morphine to mask pain. Bryant Stamford, The Courier-Journal, 26 Dec. 2024 See All Example Sentences for endorphin

Word History

Etymology

International Scientific Vocabulary endogenous + morphine

First Known Use

1976, in the meaning defined above

Time Traveler
The first known use of endorphin was in 1976

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Cite this Entry

“Endorphin.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/endorphin. Accessed 28 Mar. 2025.

Medical Definition

endorphin

noun
en·​dor·​phin en-ˈdȯr-fən How to pronounce endorphin (audio)
: any of a group of endogenous peptides (as enkephalin and dynorphin) found especially in the brain that bind chiefly to opiate receptors and produce some of the same pharmacological effects (as pain relief) as those of opiates
specifically : beta-endorphin

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