side effect

noun

: a secondary and usually adverse effect (as of a drug)
toxic side effects

called also side reaction

Examples of side effect in a Sentence

Nausea and diarrhea are the side effects of the drug. the harmful side effects of using chemicals to kill insects The merger created positive side effects for both companies.
Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Follow-up drugs may be more powerful, more selective and with side effects ironed out or controlled with combination therapies. Karen Gilchrist, CNBC, 26 Aug. 2025 However, loading doses of creatine are more associated with side effects such as water retention and symptoms like diarrhea.11 Skipping the creatine loading phase and instead taking smaller daily doses over a longer period can help minimize side effects like water retention. Jillian Kubala, Health, 26 Aug. 2025 Constipation Another side effect that is seen with calcium supplements is constipation.2 Constipation is when someone has fewer than three bowel movements per week. Patty Weasler, Verywell Health, 26 Aug. 2025 What is clear is that these medications take a long time to work, sometimes up to several weeks, and even then, the patient may need regular dosage adjustments to minimize side effects. Dr. Sanjay Gupta, CNN Money, 26 Aug. 2025 See All Example Sentences for side effect

Word History

First Known Use

1814, in the meaning defined above

Time Traveler
The first known use of side effect was in 1814

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Cite this Entry

“Side effect.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/side%20effect. Accessed 4 Sep. 2025.

Kids Definition

side effect

noun
: an often harmful and unwanted effect (as of a drug) that occurs along with the basic desired effect
the environmental side effects of using chemicals to kill pests

Medical Definition

side effect

noun
: a secondary and usually adverse effect (as of a drug)
toxic side effects
a side effect of drowsiness caused by antihistamines

called also side reaction

Last Updated: - Updated example sentences
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