: a zoonotic disease especially of central and western Africa that is caused by a poxvirus (species Monkeypox virus of the genus Orthopoxvirus), that is transmitted in humans usually by direct contact with the infectious lesions or bodily fluids of an infected person or animal, and that causes initial symptoms including fever, headache, swollen lymph glands, myalgia, and fatigue followed by skin eruptions typically on the face, hands, feet, and mouth with lesions that eventually fill with fluid before sloughing off : monkeypox
Note: This disease was first identified in monkeys in 1958, although the natural reservoir (see reservoir sense 3a) has not been identified. The mpox virus has been found in various animals including rodents and primates.
Note: The World Health Organization (WHO) announced on November 28, 2022 that it will begin using the preferred name mpox over monkeypox to refer to this disease due to the stigmatizing nature of the original name.
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Merriam-Webster unabridged
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