irritability

noun

ir·​ri·​ta·​bil·​i·​ty ˌir-ə-tə-ˈbi-lə-tē 

plural irritabilities

1

: the quality or state of being irritable: such as

a

: quick excitability to annoyance, impatience, or anger : petulance

b

: abnormal or excessive excitability of an organ or part of the body

2

: the property of protoplasm and of living organisms that permits them to react to stimuli

Synonyms

• biliousness
• choler
• crankiness
• crossness
• crotchetiness
• grouchiness
• grumpiness
• huffiness
• irascibility
• irascibleness
• irritableness
• peevishness
• perverseness
• perversity
• pettishness
• petulance
• testiness
• waspishness

Examples of irritability in a Sentence

the librarian's well-known irritability makes students hesitant to ask questions

Recent Examples on the Web

The condition can cause symptoms like exhaustion, irritability, unintentional weight loss, hand tremors, and skin discoloration, according to the Mayo Clinic. About 1 percent of Americans have Graves' disease, according to Yale Medicine. —Wesley Stenzel, EW.com, 14 June 2025

This can cause sweating, hand tremors, or irritability. —Janelle McSwiggin, Health, 14 June 2025

The symptoms can manifest in various ways, including persistent decreased mood or irritability, decreased ability to function at work, inability to be present with their baby or partner, postpartum insomnia and chronic physical symptoms like headaches or gastrointestinal upset. —Pooja Shah, Forbes.com, 13 June 2025

Mental indicators include difficulty concentrating, irritability, forgetfulness or feeling constantly on edge. —Phil Blair, San Diego Union-Tribune, 9 June 2025

Word History

First Known Use

1755, in the meaning defined at sense 2

Rhymes for irritability

• acceptability
• accessibility
• adaptability
• admissibility
• advisability
• affordability
• allowability
• amenability
• amiability
• appealability
• applicability
• availability

Kids Definition

irritability

noun

ir·​ri·​ta·​bil·​i·​ty ˌir-ət-ə-ˈbil-ət-ē 

plural irritabilities

1

: the quality or state of being irritable

especially : readiness to become annoyed or angry

2

: the property of living tissue and living things that permits them to react to stimuli

Medical Definition

irritability

noun

ir·​ri·​ta·​bil·​i·​ty ˌir-ət-ə-ˈbil-ət-ē 

plural irritabilities

1

: the property of protoplasm and of living organisms that permits them to react to stimuli

2

a

: quick excitability to annoyance, impatience, or anger

b

: abnormal or excessive excitability of an organ or part of the body (as the stomach or bladder)