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These individuals, called APOE4 homozygotes, have a 60 percent chance of developing AD by age 85.—Laura Hercher, Scientific American, 1 Aug. 2024 And this gene, unlike its more deterministic cousins, is not really rare at all; 2 percent of the U.S. population are APOE4 homozygotes.—Laura Hercher, Scientific American, 1 Aug. 2024 The findings suggest that people with two copies of the gene—who are called APOE4 homozygotes—have a distinct genetic form of Alzheimer’s.—Will Sullivan, Smithsonian Magazine, 7 May 2024 Analyzing data from more than 13,000 people, researchers found that among APOE4 homozygotes, people who carry two copies of the gene variant, nearly all showed biological signs of Alzheimer’s in the brain.—Elaine Chen Reprints, STAT, 7 May 2024 Most of you have seen a Punnet square, whereby heterozygous parents will produce offspring in ratios where 50% are heterozygous, and 25% one homozygote and 25% another.—Razib Khan, Discover Magazine, 17 Aug. 2010 Interestingly the persistent individual in the Longar location also a homozygote.—Razib Khan, Discover Magazine, 16 Jan. 2012 Another reason may be that in the original parental lineages there was a higher fraction of alleles which were deleterious in homozygote genotypes.—Razib Khan, Discover Magazine, 12 Aug. 2010 The mother is probably a heteozygote, and the father is a homozygote.—Razib Khan, Discover Magazine, 13 Oct. 2011
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