genetic mutation

noun

plural genetic mutations

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.

—Natalie Angier

Examples of genetic mutation in a Sentence

Recent Examples on the Web

The cause behind developing multiple penises is generally believed to stem from genetic mutations affecting androgen receptors during development. —Andrew Paul, Popular Science, 16 Oct. 2024

Some people with Carney complex do not have this genetic mutation. —Kelly Burch Published, Verywell Health, 2 Oct. 2024

Not all genetic mutations are detected, and sometimes results are unclear, leaving you with variants of unknown significance (VUS) that don’t provide a clear answer. —Sandra Rose Salathe, Flow Space, 3 Oct. 2024

The condition is caused by a genetic mutation that leads to skin discoloration and tumor growth throughout the body. —Kelly Burch Published, Verywell Health, 2 Oct. 2024

Word History

First Known Use

1915, in the meaning defined above

Medical Definition

genetic mutation

noun

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.

—Joseph Alper