genetic mutation

noun

plural genetic mutations

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.

—Natalie Angier

Examples of genetic mutation in a Sentence

Recent Examples on the Web

When a plasma cell has a genetic mutation, the cell becomes abnormal and may become cancerous.1 Researchers aren't certain what causes the cell mutations that lead to multiple myeloma but have proposed several theories: Oncogene Changes Oncogenes are genes that control how a cell grows and divides. —Carrie Madormo, Rn, Health, 17 Jan. 2025

Unlike adults, children's genetic mutations are rarely caused by lifelong exposures to carcinogens. —Alexis Kayser, Newsweek, 15 Jan. 2025

The authors believed that the unknown genetic mutation present in this bird disrupted the metabolic pathway that helps the body synthesize red carotenoids. —Laura Baisas, Popular Science, 9 Jan. 2025

After sequencing viral specimens collected from the severely ill patient in Louisiana, the CDC announced on Thursday that genetic mutations had been identified in some of the samples. —Elizabeth Yuko, Rolling Stone, 31 Dec. 2024

Word History

First Known Use

1915, in the meaning defined above

Medical Definition

genetic mutation

noun

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.

—Joseph Alper