genetic mutation

noun

plural genetic mutations
: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes
Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.Natalie Angier

Examples of genetic mutation in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
This discrepancy surprised us because the genetic mutation that causes melanism occurs less frequently than the one that causes albinism/leucism. Elizabeth Carlen, Discover Magazine, 31 Oct. 2024 The cause behind developing multiple penises is generally believed to stem from genetic mutations affecting androgen receptors during development. Andrew Paul, Popular Science, 16 Oct. 2024 Some people with Carney complex do not have this genetic mutation. Kelly Burch Published, Verywell Health, 2 Oct. 2024 Not all genetic mutations are detected, and sometimes results are unclear, leaving you with variants of unknown significance (VUS) that don’t provide a clear answer. Sandra Rose Salathe, Flow Space, 3 Oct. 2024 See all Example Sentences for genetic mutation 

Word History

First Known Use

1915, in the meaning defined above

Time Traveler
The first known use of genetic mutation was in 1915

Dictionary Entries Near genetic mutation

Cite this Entry

“Genetic mutation.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/genetic%20mutation. Accessed 22 Nov. 2024.

Medical Definition

genetic mutation

noun
: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes
Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.Joseph Alper
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