downregulation
noun
down·reg·u·la·tion
ˈdau̇n-ˌreg-yə-ˈlā-shən
: the process of reducing or suppressing a response to a stimulus
specifically
: reduction in a cellular response to a molecule (as insulin) due to a decrease in the number of receptors on the cell surface
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Merriam-Webster unabridged
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