cortisol

noun

cor·​ti·​sol ˈkȯr-tə-ˌsȯl 

-ˌzȯl,

-ˌsōl,

-ˌzōl

: a glucocorticoid C₂₁H₃₀O₅ produced by the adrenal cortex upon stimulation by ACTH that mediates various metabolic processes (such as gluconeogenesis), has anti-inflammatory and immunosuppressive properties, and whose levels in the blood may become elevated in response to physical or psychological stress

called also hydrocortisone

Examples of cortisol in a Sentence

Recent Examples on the Web

Psychologist Kati Morton says using apps like Insight Timer and Headspace for even five to 10 minutes can reduce cortisol levels and improve emotional regulation. —Anna Haines, Forbes.com, 8 May 2025

Caffeine and alcohol may increase cortisol level as well. —Heidi Moawad, Verywell Health, 7 May 2025

Lack of sleep can contribute to weight gain and trigger an increase in cortisol levels, which impacts blood sugar and triggers insulin resistance. —Sherri Gordon, Health, 1 May 2025

High cortisol levels and persistent anxiety prevent deep, restorative sleep, leaving you feeling exhausted even after a full night in bed. —Dr. Jamin Brahmbhatt, CNN Money, 16 Apr. 2025

Word History

Etymology

cortisone + -ol entry 1

First Known Use

1951, in the meaning defined above

Rhymes for cortisol

• aerosol
• alcohol
• arbitral
• basketball
• butanol
• cannonball
• carbinol
• catarrhal
• ethanol
• fireball
• gasohol
• guaiacol

Medical Definition

cortisol

noun

cor·​ti·​sol ˈkȯrt-ə-ˌsȯl, -ˌzȯl, -ˌsōl, -ˌzōl 

: a glucocorticoid C₂₁H₃₀O₅ produced by the adrenal cortex upon stimulation by ACTH that mediates various metabolic processes (as gluconeogenesis), has anti-inflammatory and immunosuppressive properties, and whose levels in the blood may become elevated in response to physical or psychological stress

called also hydrocortisone