break·through
ˈbrāk-ˌthrü 
plural breakthroughs
1
a
: a sudden advance especially in knowledge or technique
a medical breakthrough
b
: a person's first notable success
—often used before another noun
a breakthrough novel
the actress's breakthrough performance
2
a
: an act or instance of moving through or beyond an obstacle
a breakthrough in the talks between the region's leaders
a breakthrough agreement
b
: an instance of passing through a barrier or protection
The ice under the surface begins to deteriorate, increasing the risk of breakthroughs.—
Vicki Winger
Vicki Winger
specifically, medical
: infection occurring in someone who is fully vaccinated against an infectious agent
A vaccine breakthrough occurs when a person tests positive for COVID-19 two weeks after being fully vaccinated against the disease … —David Rasbach
—often used before another noun David Rasbach Two other CDC studies of breakthrough cases at nursing homes showed the vaccines protected residents, even when the virus spread through the homes. —Maura Dolan
Maura Dolan … the academy recently recommended that children receive two doses of the chicken pox vaccine, rather than just one, because the additional dose bolsters immunity and may help reduce breakthrough infection. —Maria Raven
Maria Raven 3
warfare
: an offensive military assault that penetrates and carries beyond a defensive line
broke through; broken through; breaking through; breaks through
: to make a breakthrough
Synonyms
Examples of breakthrough in a Sentence
Noun
Researchers say they have made a major breakthrough in cancer treatment.
The police have announced a breakthrough in the murder case.
This job could be the breakthrough she's been waiting for.
Recent Examples on the Web
Seth Klamann, The Denver Post, 21 Dec. 2024
Prime Target follows Woodall’s Edward Brooks, a math genius (hence the reference to prime numbers) on the brink of a major breakthrough who senses someone may be trying to thwart his discovery.
—Lucy Ford, TIME, 20 Dec. 2024
Justin Worland, TIME, 20 Dec. 2024
This Christmas, allow that message to break through all the clutter.
—Chris Roemer, Baltimore Sun, 19 Dec. 2024
See all Example Sentences for breakthrough 
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Noun
The breakthrough, described in a New England Journal of Medicine paper and presented at a conference in mid-December, is called blinatumomab, an immunotherapy drug delivered to patients over a 28-day IV drip.
—Seth Klamann, The Denver Post, 21 Dec. 2024
Prime Target follows Woodall’s Edward Brooks, a math genius (hence the reference to prime numbers) on the brink of a major breakthrough who senses someone may be trying to thwart his discovery.
—Lucy Ford, TIME, 20 Dec. 2024
Verb
But those efforts often struggled to break through the noise.
—Justin Worland, TIME, 20 Dec. 2024
This Christmas, allow that message to break through all the clutter.
—Chris Roemer, Baltimore Sun, 19 Dec. 2024
See all Example Sentences for breakthrough
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Dictionary Entries Near breakthrough
Cite this Entry
“Breakthrough.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/breakthrough. Accessed 26 Dec. 2024.
Copy CitationKids Definition
breakthrough
noun
break·through
ˈbrāk-ˌthrü
: a sudden advance in knowledge or technique
a breakthrough in medical science
Medical Definition
breakthrough
noun
break·through
ˈbrāk-ˌthrü
: infection occurring in someone who is fully vaccinated against an infectious agent
—often used before another noun
breakthrough infections
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