antidepressant

1 of 2

adjective

an·​ti·​de·​pres·​sant ˌan-tē-di-ˈpre-sᵊnt How to pronounce antidepressant (audio) ˌan-ˌtī- How to pronounce antidepressant (audio)
: used or tending to relieve or prevent depression
antidepressant drugs

antidepressant

2 of 2

noun

Examples of antidepressant in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Adjective
In the story an antidepressant pharmaceutical company accidentally creates a love virus. Joan MacDonald, Forbes.com, 21 Apr. 2025 Inflammation and metabolic dysfunction underly anhedonia-like behavior in antidepressant resistant male rats Before joining Discover Magazine, Paul Smaglik spent over 20 years as a science journalist, specializing in U.S. life science policy and global scientific career issues. Paul Smaglik, Discover Magazine, 2 Apr. 2025
Noun
It has previously been proposed that probiotics — like antidepressants — may reduce both positive and negative emotions, according to the report. Khloe Quill, FOXNews.com, 23 Apr. 2025 This marks a notable increase over more conventional antidepressant therapy treatments, whose remission rates hover around 45 percent. John Semley, Rolling Stone, 19 Apr. 2025 See All Example Sentences for antidepressant

Word History

First Known Use

Adjective

1961, in the meaning defined above

Noun

1962, in the meaning defined above

Time Traveler
The first known use of antidepressant was in 1961

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Cite this Entry

“Antidepressant.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/antidepressant. Accessed 29 Apr. 2025.

Medical Definition

antidepressant

1 of 2 adjective
an·​ti·​de·​pres·​sant ˌant-i-di-ˈpres-ᵊnt, ˌan-ˌtī- How to pronounce antidepressant (audio)
variants also antidepressive
: used or tending to relieve or prevent psychological depression : relating to, being, or utilizing an antidepressant
an antidepressant drug
antidepressant treatment

antidepressant

2 of 2 noun
variants also antidepressive
: a drug used to treat psychological depression : an antidepressant drug
The dual-action antidepressant venlafaxine appears to demonstrate superior efficacy and higher rates of remission in severe depression as compared with either SSRIs such as fluoxetine or tricyclic antidepressants.John Mann, The New England Journal of Medicine

called also energizer, psychic energizer, psychostimulant

see tricyclic antidepressant
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