amyotrophic lateral sclerosis

noun

amyo·​tro·​phic lateral sclerosis ˌā-ˌmī-ə-ˈtrō-fik- How to pronounce amyotrophic lateral sclerosis (audio) -ˈträ- How to pronounce amyotrophic lateral sclerosis (audio)
: a rare progressive degenerative fatal disease affecting the motor neurons, usually beginning in middle age, and characterized especially by increasing and spreading muscular weakness and atrophy
abbreviation ALS

called also Lou Gehrig's disease

Examples of amyotrophic lateral sclerosis in a Sentence

Recent Examples on the Web
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Herb Wiley, a guitarist in Rye Coalition and the Black Hollies, revealed last week that he has been diagnosed with amyotrophic lateral sclerosis (ALS), the rare neurodegenerative disorder that’s also known as Lou Gehrig’s disease. Jazz Monroe, Pitchfork, 28 Apr. 2025 The Ice Bucket Challenge was created in 2014 to raise awareness for amyotrophic lateral sclerosis (ALS). Zoey Lyttle, People.com, 25 Apr. 2025 Eric Dane, known for his roles as Dr. Mark Sloan in Grey's Anatomy and Cal Jacobs in HBO's Euphoria, has revealed he has been diagnosed with amyotrophic lateral sclerosis (ALS), a rare and progressive neurological disease. David Faris, MSNBC Newsweek, 11 Apr. 2025 Veteran actor Eric Dane shared that he was diagnosed with amyotrophic lateral sclerosis (ALS), a rare degenerative disease that affects nerve cells in the brain and spinal cord. Charisma Madarang, Rolling Stone, 10 Apr. 2025 See All Example Sentences for amyotrophic lateral sclerosis

Word History

Etymology

a- entry 2 + my- + -trophic

First Known Use

1875, in the meaning defined above

Time Traveler
The first known use of amyotrophic lateral sclerosis was in 1875

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Cite this Entry

“Amyotrophic lateral sclerosis.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/amyotrophic%20lateral%20sclerosis. Accessed 20 May. 2025.

Medical Definition

amyotrophic lateral sclerosis

noun
: a rare fatal progressive degenerative disease that affects pyramidal motor neurons, usually begins in middle age, and is characterized especially by increasing and spreading muscular weakness
abbreviation ALS

called also Lou Gehrig's disease

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