amitriptyline

noun

am·​i·​trip·​ty·​line ˌa-mə-ˈtrip-tə-ˌlēn 

: a tricyclic aromatic antidepressant drug used in the form of its hydrochloride C₂₀H₂₃N·HCl to prevent migraines and to treat neuropathic pain, bulimia, and depression

Examples of amitriptyline in a Sentence

Recent Examples on the Web

Lindsay was discharged from McLean after only five days, with a prescription for the antidepressant amitriptyline, Pat recalled—her thirteenth medication in a span of four months. —Eren Orbey, The New Yorker, 14 Oct. 2024

Other medications: Medications that have varied actions include estrogen therapy, imipramine, and amitriptyline. —Matthew Wosnitzer, Verywell Health, 8 July 2024

This list includes beta-blockers such as propranolol, anticonvulsants such as (topiramate) and Depakote (divalproex), and antidepressants such as amitriptyline and Effexor (venlafaxine). —Syeda Khaula Saad, Verywell Health, 3 Apr. 2024

Medicines that are more specific for nerve pain, such as gabapentin or amitriptyline, are usually more effective than opiate-type medications in the long-term. —Dr. Keith Roach, oregonlive, 18 Sep. 2023

Word History

Etymology

ami(no) + trypt(ophan) + -yl + -ine entry 2

First Known Use

1961, in the meaning defined above

Medical Definition

amitriptyline

noun

am·​i·​trip·​ty·​line ˌam-ə-ˈtrip-tə-ˌlēn 

: a tricyclic antidepressant drug that is administered in the form of its hydrochloride C₂₀H₂₃N·HCl to prevent migraines and to treat neuropathic pain, bulimia, and depression