allostatic load

noun

: the cumulative adverse effect on the body when allostasis occurs too frequently (as when the body is subjected to repeated stressors) or is inadequate

Over weeks, months, or years, exposure to increased secretion of stress hormones can result in allostatic load and its pathophysiologic consequences.

—Bruce S. McEwen, New England Journal of Medicine, 15 Jan. 1998

Word History

First Known Use

1996, in the meaning defined above

The Ultimate Dictionary Awaits

Expand your vocabulary and dive deeper into language with Merriam-Webster Unabridged.

1. Expanded definitions
2. Detailed etymologies
3. Advanced search tools
4. All ad-free

Discover what makes Merriam-Webster Unabridged the essential choice for true word lovers.

Start Your Free Trial Now