Down syndrome
noun
variants
or Down's syndrome
: a congenital condition characterized especially by developmental delays, usually mild to moderate impairment in cognitive functioning, short stature, upward slanting eyes, a flattened nasal bridge, broad hands with short fingers, decreased muscle tone, and by trisomy of the human chromosome numbered 21
called also trisomy 21
Examples of Down syndrome in a Sentence
Recent Examples on the Web
Following the passing of his wife, a devoted father learns to raise his son with Down syndrome as a single parent.
—
Kate Erbland, IndieWire, 23 Apr. 2025
Donut Run benefits Down syndrome community GiGi’s Playhouse San Diego, a Down syndrome achievement center, will host its annual Donut Run 5K from 8 a.m. to noon April 27 at Crown Point Shores North, 700 Corona Oriente Road.
—Ut Community Press, San Diego Union-Tribune, 23 Apr. 2025
Her daughter, who has Down syndrome, was in a special-needs general curriculum class, when the school board decided to include books that talk about LGBTQ+ children and parents.
—Nina Totenberg, NPR, 22 Apr. 2025
The ability to customize provided the opportunity to accommodate their youngest son, 11-year-old Fil, who has Down syndrome.
—Katia Damborsky, Robb Report, 20 Apr. 2025
See All Example Sentences for Down syndrome
Examples are automatically compiled from online sources to
show current usage.
Read More
Opinions expressed in the examples do not represent those of Merriam-Webster or its editors.
Send us feedback.
Kate Erbland, IndieWire, 23 Apr. 2025
Donut Run benefits Down syndrome community GiGi’s Playhouse San Diego, a Down syndrome achievement center, will host its annual Donut Run 5K from 8 a.m. to noon April 27 at Crown Point Shores North, 700 Corona Oriente Road.
—Ut Community Press, San Diego Union-Tribune, 23 Apr. 2025
Her daughter, who has Down syndrome, was in a special-needs general curriculum class, when the school board decided to include books that talk about LGBTQ+ children and parents.
—Nina Totenberg, NPR, 22 Apr. 2025
The ability to customize provided the opportunity to accommodate their youngest son, 11-year-old Fil, who has Down syndrome.
—Katia Damborsky, Robb Report, 20 Apr. 2025
See All Example Sentences for Down syndrome
Cite this Entry
“Down syndrome.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/Down%20syndrome. Accessed 29 Apr. 2025.
Copy CitationLove words? Need even more definitions?
Merriam-Webster unabridged
Share